|
KMID : 0043319950180010018
|
|
Archives of Pharmacal Research
1995 Volume.18 No. 1 p.18 ~ p.21
|
|
|
Drug Release from Bioerodible Hydrogels Composed of Poly-ε-caprolactone/poly(ethylene glycol) Macromer Semiinterpenhetrating Polymer Networks
|
|
Kim Sung-Ho
Ha Jeong-Hun
Jung Yong-Jae
Cho Chong-Su
|
|
|
Abstract
|
|
|
|
Poly(ethylene glycol)(PEG) macrocers teminated with acrylate groups and semi-interpenetrating polymer networks (IPNs) composed of poly-.epsilon.-capolactone(PCL) and PEG macromer were syntheswized with the aim of obtaining a bioerodible hydrogel that could be used to release drugs for implantable delivery system. Polymerization of PEG macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Non-crosslinked PCL chains were interpenetrated into the cross-linked three-dimensions networks of PEG. The IPNs, largw drug loading lower concentration of PEG macromer in the IPNs concentration and the higher molecular weight of PEG macromer. Also, 5-FU was more fast released than hydrocortisone to the increased water solubility.
|
|
|
KEYWORD
|
|
|
PEG macromer, IPNs, PCL, Bioerodible, Hydrogel
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|